Sorbitan sesquioleata
SORBITAN SESQUIOLEATE
CAS: 8007-43-0
Molecular Formula: C66H126O16
Sorbitan sesquioleata - Names and Identifiers
| Name | SORBITAN SESQUIOLEATE |
| Synonyms | SPAN 83 crill16 crillk16 emasol41s SPAN NO 83 SORBITAN SESQUIOLEATE Sorbitan sesquioleata anhydrohexitolsesquioleate |
| CAS | 8007-43-0 |
| EINECS | 232-360-1 |
| InChIKey | SPFRYHCSFBFNTR-RKGWDQTMSA-N |
Sorbitan sesquioleata - Physico-chemical Properties
| Molecular Formula | C66H126O16 |
| Molar Mass | 1175.7 |
| Density | 0.989g/mLat 25°C(lit.) |
| Flash Point | 113°C |
| Water Solubility | Insoluble in cold water, hot water. soluble in mineral oil and ethyl acetate. |
| Solubility | Dispersible in water, soluble in fatty oils, slightly soluble in ethanol. |
| Vapor Presure | 0.81 psi ( 20 °C) |
| Appearance | Viscous Liquid |
| Color | Pale Yellow |
| pKa | 13.11[at 20 ℃] |
| Refractive Index | n20/D 1.478(lit.) |
| Physical and Chemical Properties | This product is Amber to brown oily liquid, a small amount of soluble in cottonseed oil, mineral oil, tetrachloroethylene, isopropanol. |
| Use | Use of this product in medicine, cosmetics, textile, paint industry as emulsifier, solubilizer, stabilizer, softener, antistatic agent. |
Sorbitan sesquioleata - Risk and Safety
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | WG2934330 |
| TSCA | Yes |
Sorbitan sesquioleata - Study on the Relationship between Quality Index of Sipan -80 and Emulsion Stability
From VIP
Author:
Summary:
the relationship between the relevant indexes of span -80 and the stability of emulsion is introduced. the experimental results show that increasing the content of esterified substances and reducing the water content within a certain range are beneficial to the improvement of the stability of emulsion. the acid value of span -80 produced by oleic acid of different quality has no comparable effect on the stability of emulsion.
keywords:
emulsion stability quality index surfactant Non-ionic type
DOI:
CNKI:SUN:LNHG. 0.2000-03-005
cited:
Year:
2000
Last Update：2024-01-02 23:10:35
Sorbitan sesquioleata - Preparation of Span-polyethylene glycol ultrasonic contrast agent microbubbles with folic acid-carbon nanotubes-paclitaxel
From VIP Journal Professional Edition
Author:
Liu junxi , Zhang Jie , Zhang Yu , Zhao Yue , Wan Guojing ,< a href = "https://xueshu.baidu.com/s?wd=author: (Li Guozhong) & tn = SE_baiduxueshu_c1gjeupa & ie = utf-8 & SC _f_para = SC _hilight = person" target = "_blank"> Li Guozhong
Summary:
Background: Traditional ultrasound contrast agents have a single function, and their sensitivity, clarity and accuracy are greatly affected by objective factors, so they cannot realize the functions of diagnosis and treatment at the same time. Carbon nanotubes have a special network hollow lumen structure and have the potential to enhance development. Functionalized carbon nanotubes are obtained by non-covalent adsorption, covalent bonding and internal embedding, with good biocompatibility and high drug loading rate. Based on this, the drug-loaded carbon nanotubes were added into the ultrasonic contrast agent microbubble structure to prepare a new type of multifunctional ultrasonic contrast agent microbubble for the composite carbon nanotube carrier system. Objective: To prepare Span-PEG (Span-PEG) ultrasonic contrast microbubbles composite with folate-carbon nanotubes-paclitaxel (folate-carbon nano-tube-paclitaxel,FA-CNTs-PTX), and to study the morphology, particle size and loading rate of carbon nanotubes and paclitaxel in microbubbles. Methods: Span-PEG microbubbles were prepared by acoustic vibration cavitation method, and the preparation process was optimized by orthogonal experiment, and then the FA-CNTs-PTX intermediate was synthesized by electrostatic self-assembly, & pi;-& pi; Adsorption and other principles. Then, the FA-CNTs-PTX intermediate was compounded in Span-PEG microbubbles to obtain the FA-CNTs-PTX Span-PEG ultrasound contrast agent microbubbles. The morphology of microbubbles was observed by scanning electron microscope and transmission electron microscope. The particle size distribution and average particle size of microbubbles were determined by laser particle size analyzer. The loading rate of carbon nanotubes and paclitaxel in microbubbles was determined by ultraviolet spectrophotometry. Results and Conclusion: The Span-PEG microbubble of the prepared composite FA-CNTs-PTX has a smooth surface with an average particle size of 442 nm. The loading rates of carbon nanotubes and paclitaxel in the microbubble are 1.69% and 47.9% respectively. The FA-CNTs-PTX targeted drug-loaded complex was successfully coated in Span-PEG microbubbles. The microbubbles are hollow spheres with uniform particle size distribution and nano-level. The composite microbubbles are expected to become an ultrasonic contrast agent integrating imaging and targeted therapy.
expand
keywords:
ultrasonics nanotubes, carbon tissue engineering biomaterial nanomaterial ultrasonic contrast agent diagnosis treatment targeting carbon nanotubes electrostatic self-assembly paclitaxel folic acid national natural science foundation
DOI:
10.3969/j.issn.2095-4344.2017.02.018
cited:
Year:
2017
Last Update：2023-08-16 22:09:50
Sorbitan sesquioleata - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| use | this product is used as emulsifier, solubilizer, stabilizer, softener and antistatic agent in medicine, cosmetics, textile and paint industries. |
| production method | put 1 mol of sorbitol into the reaction kettle, dehydrate under reduced pressure, then press the refined oleic acid into the reaction kettle, and then add the catalyst amount of sodium hydroxide. Under stirring, vacuumize, gradually raise the temperature to about 200 ℃, and maintain the reaction for 8 h. The acid value is measured by sampling, and the esterification reaction is over when the acid value reaches about 12. Cool and let stand for 24, after the reaction liquid is layered, the lower layer of dark liquid is thrown into the decolorization kettle, and the upper layer of liquid is decolorized with hydrogen peroxide at 50~60 ℃ for 1 h. Continue to vacuum dehydrate, dehydrate at 110 ℃ for 5 h, and the reaction is completed, and the finished product is finished after discharging and filling. |
Last Update：2024-04-09 15:16:44
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